VRAYLAR is a prescription medicine approved as an add-on therapy for adults with depression who are currently taking an antidepressant but still have unresolved depression symptoms.
How could VRAYLAR help me?
You’ve made progress with your antidepressant. Adding VRAYLAR can give it a lift and may help get you where you want to be.
You’ve made progress with your antidepressant. Adding VRAYLAR can give it a lift and may help get you where you want to be.
Adding VRAYLAR to an antidepressant is clinically proven to help relieve overall depression symptoms better than an antidepressant alone.
In 6- and 8-week studies†, adults, on average, experienced improvement in their overall depression symptoms after adding VRAYLAR to their antidepressant vs an antidepressant alone.
†Individual results may vary

VRAYLAR is a once-daily capsule that works with your antidepressant. VRAYLAR also works differently than your antidepressant. While the exact way VRAYLAR works is unknown, healthcare providers and scientists believe that VRAYLAR helps manage chemicals in the brain, such as serotonin and dopamine, that may control your mood.
How do I take VRAYLAR?
Treatments like VRAYLAR start working gradually. Every patient is different. So, it’s important to stick with your treatment plan and talk to your healthcare provider about how VRAYLAR is working for you.
Things to keep in mind when taking VRAYLAR
What antidepressants could I take with VRAYLAR?
Examples of common primary antidepressants that were taken with VRAYLAR in clinical studies‡,§
SSRI
antidepressant
Prozac® (fluoxetine)
Paxil® (paroxetine)
Zoloft® (sertraline)
SNRI
antidepressant
Cymbalta® (duloxetine)
Effexor® (venlafaxine)
NDRI
antidepressant
Wellbutrin® (bupropion hydrochloride)
SSRI = selective serotonin reuptake inhibitor; SNRI = serotonin and norepinephrine reuptake inhibitor; NDRI = norepinephrine and dopamine reuptake inhibitor
‡These are not all the antidepressants studied with VRAYLAR. Ask your healthcare provider if adding VRAYLAR is right for you.
§All trademarks are property of their respective owners.
What are the most common side effects of VRAYLAR?
The most common side effects of Vraylar include difficulty moving or slow movements,
tremors, uncontrolled body movements, restlessness and feeling like you need to move around,
sleepiness, nausea, vomiting, indigestion, constipation, feeling tired, trouble sleeping, increased
appetite, and dizziness.
Tell your healthcare provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of VRAYLAR.
Will I gain weight while on VRAYLAR?


Most people taking VRAYLAR + antidepressant (ADT) saw no substantial impact on weight.
In VRAYLAR clinical studies, weight change reported was ≤1.5lb.
Weight gain may occur. You and your doctor should monitor your weight regularly.
Average weight change in 6-week major depressive disorder studies:

In clinical studies, 98% of patients in 6-week trials and 81% of patients in a 6-month trial had no substantial weight gain (defined by ≥7% change). In the 6-month study, the average weight gain in VRAYLAR-treated patients was 3.7 lb.
Weight gain may occur. You and your doctor should monitor your weight regularly.
Can I anticipate any sexual side effects when adding VRAYLAR?
In clinical studies, less than 1% of patients taking
VRAYLAR with their antidepressant reported sexual side effects||
In clinical studies, less than 1% of
patients taking VRAYLAR with
their antidepressant reported
sexual side effects||
|
Placebo |
VRAYLAR |
VRAYLAR |
|
Abnormal Orgasm |
0% |
0% |
0.2% |
|
Decreased Sex Drive |
0% |
0.2% |
0% |
|
Erectile Dysfunction |
0% |
0.2% |
0% |
|
Ejaculation Failure |
0% |
0.2% |
0% |
|
Ejaculation Disorder |
0% |
0% |
0% |
||These adverse events were self-reported by patients in 6 week studies.
Looking for a lift in relief?
If you need more from your antidepressant, adding VRAYLAR could help.