What is
VRAYLAR?
VRAYLAR is approved as an add-on prescription medication for major depressive disorder in adults who are currently taking an antidepressant but still have unresolved depression symptoms.
How could VRAYLAR help me?
You’ve made progress with your antidepressant, but depressive symptoms may still leave you feeling stuck. Taking VRAYLAR as an add-on for depression can give your symptoms a lift and may help you get where you want to be.
Adding VRAYLAR to an antidepressant is clinically proven to help relieve overall depression symptoms better than an antidepressant alone.
In 6- and 8-week studies,† adults, on average, experienced improvement in their overall depression symptoms after adding VRAYLAR to their antidepressant vs an antidepressant alone.
†Individual results may vary.
How does VRAYLAR work?
VRAYLAR is a once-daily capsule that is taken with your antidepressant.
VRAYLAR works differently than your antidepressant. While the exact way VRAYLAR works is unknown, healthcare providers and scientists believe that VRAYLAR helps regulate dopamine and serotonin in the brain.
Watch the video to learn more about how VRAYLAR is thought to work.
How do I take VRAYLAR?
One pill
Once a day
With or without food
Things to keep in mind when taking VRAYLAR
Treatments like VRAYLAR start working gradually. Every patient is different, so it’s important to stick with your treatment plan. Do not stop taking VRAYLAR or change how much you take without checking with your healthcare provider first.
Hear about Kami’s experience with VRAYLAR
Kami was diagnosed with major depressive disorder. Even though she was taking an antidepressant, she still struggled with lingering depression symptoms. Watch Kami's story and see her experience with adding VRAYLAR to her antidepressant and how it helped reduce her depression symptoms.
The person featured in this video is sharing her individual experience with VRAYLAR. Individual experiences with the condition and treatment will vary. Talk to your healthcare provider to see if VRAYLAR may be right for you.
What antidepressants could I take with VRAYLAR?
Examples of common antidepressants that were taken with VRAYLAR in the clinical studies‡§:
SSRI antidepressants
Prozac® (fluoxetine)
Paxil® (paroxetine)
Zoloft® (sertraline)
SNRI antidepressants
Cymbalta® (duloxetine)
Effexor® (venlafaxine)
NDRI antidepressant
Wellbutrin® (bupropion hydrochloride)
SSRI=selective serotonin reuptake inhibitor; SNRI=serotonin and norepinephrine reuptake inhibitor; NDRI=norepinephrine and dopamine reuptake inhibitor.
‡These are not all the antidepressants studied with VRAYLAR. Ask your healthcare provider if adding VRAYLAR is right for you.
§All trademarks are property of their respective owners.
Make the most out of your appointment
Help your provider understand how you’re feeling. Complete this simple quiz about your symptoms to create a personalized discussion guide for your next appointment.
What are some of the possible side effects of VRAYLAR?
The most common side effects include difficulty moving or slow movements, tremors, uncontrolled body movements, restlessness and feeling like you need to move around, sleepiness, nausea, vomiting, indigestion (upset stomach), constipation, feeling tired, trouble sleeping, increased appetite, and dizziness.
Tell your healthcare provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of VRAYLAR.
Does VRAYLAR cause weight gain?
Most people taking VRAYLAR + antidepressant (ADT) saw no substantial impact on weight.
Average weight change in 6-week major depressive disorder studies:
In clinical studies, 98% of patients in 6-week trials and 81% of patients in a 6-month trial had no substantial weight gain (defined by ≥7% change). In the 6-month study, the average weight gain in VRAYLAR-treated patients was 3.7 lb.
Weight gain may occur. You and your doctor should monitor your weight regularly.
||VRAYLAR 1.5 mg/day and 3.0 mg/day.
ADT=antidepressant.
Can I anticipate any sexual side effects when adding VRAYLAR?
In clinical studies, less than 1% of patients taking VRAYLAR with their antidepressant reported sexual side effects¶
| Placebo + ADT (n=503) |
VRAYLAR 1.5 mg/day + ADT (n=502) |
VRAYLAR 3 mg/day + ADT (n=503) |
|
|---|---|---|---|
| Abnormal orgasm | 0% | 0% | 0.2% |
| Decreased sex drive | 0% | 0.2% | 0% |
| Erectile dysfunction | 0% | 0.2% | 0% |
| Ejaculation failure | 0% | 0.2% | 0% |
| Ejaculation disorder | 0% | 0% | 0% |
¶These adverse events were self-reported by patients in 6-week studies.
Test your knowledge: myth or fact?
Do you know the truth about depression and its treatments? Choose whether the statements are myths or facts.
There are several options that can be effective at managing depression, even when you feel stuck. It’s important to work with your healthcare team to find the treatment(s)—medication, therapy, and lifestyle changes—that work for you.
Ready to share your VRAYLAR story?
Have you taken VRAYLAR and want to tell your story?
Just call 1-(833)-718-18351-(833)-718-1835 or email info@speaknetwork.net
Everyone’s journey with depression is different. Get helpful resources
and support to help you stay on track with your prescribed treatment plan.
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