What is

VRAYLAR is a prescription medicine approved as an add-on therapy for adults with depression who are currently taking an antidepressant but still have unresolved depression symptoms.

How could VRAYLAR help me?

You’ve made progress with your antidepressant. Adding VRAYLAR can give it a lift and may help get you where you want to be.

Adding VRAYLAR to an antidepressant is clinically proven to help relieve overall depression symptoms better than an antidepressant alone.

In 6- and 8-week studies, adults, on average, experienced improvement in their overall depression symptoms after adding VRAYLAR to their antidepressant vs an antidepressant alone.

Individual results may vary

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How does VRAYLAR work?

VRAYLAR is a once-daily capsule that works with your antidepressant. VRAYLAR also works differently than your antidepressant. While the exact way VRAYLAR works is unknown, healthcare providers and scientists believe that VRAYLAR helps manage chemicals in the brain, such as serotonin and dopamine, that may control your mood.

How do I take VRAYLAR?

Treatments like VRAYLAR start working gradually. Every patient is different. So, it’s important to stick with your treatment plan and talk to your healthcare provider about how VRAYLAR is working for you.

Things to keep in mind when taking VRAYLAR

Once daily icon.

One Pill. Take Once a Day

It’s important that you take your prescribed dose of VRAYLAR as directed, even if you start to feel better.

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Take by Mouth

Do not stop taking VRAYLAR or change how much you take without checking with your healthcare provider first.

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With or Without Food

Take VRAYLAR once a day, with or without food.

What antidepressants could I take with VRAYLAR?

Examples of common primary antidepressants that were taken with VRAYLAR in clinical studies‡,§


Prozac® (fluoxetine)

Paxil® (paroxetine)

Zoloft® (sertraline)


Cymbalta® (duloxetine)

Effexor® (venlafaxine)


Wellbutrin® (bupropion hydrochloride)

SSRI = selective serotonin reuptake inhibitor; SNRI = serotonin and norepinephrine reuptake inhibitor; NDRI = norepinephrine and dopamine reuptake inhibitor

These are not all the antidepressants studied with VRAYLAR. Ask your healthcare provider if adding VRAYLAR is right for you.

§All trademarks are property of their respective owners.

What are the most common side effects of VRAYLAR?

The most common side effects of Vraylar include difficulty moving or slow movements,
tremors, uncontrolled body movements, restlessness and feeling like you need to move around,
sleepiness, nausea, vomiting, indigestion, constipation, feeling tired, trouble sleeping, increased
appetite, and dizziness.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of VRAYLAR.

Will I gain weight while on VRAYLAR?

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Most people taking VRAYLAR + antidepressant (ADT) saw no substantial impact on weight.

In VRAYLAR clinical studies, weight change reported was ≤1.5lb.

Weight gain may occur. You and your doctor should monitor your weight regularly.

Average weight change in 6-week major depressive disorder studies:

Average weight change in 6 week major depressive disorder studies for the placebo plus ADT was 0.4 lb, VRAYLAR 1.5mg per day plus ADT was 1.5 lb, and VRAYLAR 3.0 mg per day plus ADT was 1.5 lb.

In clinical studies, 98% of patients in 6-week trials and 81% of patients in a 6-month trial had no substantial weight gain (defined by ≥7% change). In the 6-month study, the average weight gain in VRAYLAR-treated patients was 3.7 lb.

Weight gain may occur. You and your doctor should monitor your weight regularly.

Can I anticipate any sexual side effects when adding VRAYLAR?

In clinical studies, less than 1% of
patients taking VRAYLAR with
their antidepressant reported
sexual side effects||


N = 503

1.5 mg/day + ADT
N = 502


3 mg/day + ADT
N = 503

Abnormal Orgasm





Decreased Sex Drive





Erectile Dysfunction





Ejaculation Failure





Ejaculation Disorder





Looking for a lift in relief?

If you need more from your antidepressant, adding VRAYLAR could help.

If you are still dealing with symptoms of depression, try tracking how you are feeling. Fill out our symptom tracker and ask your provider if adding VRAYLAR can help.