Is VRAYLAR right for you?
VRAYLAR works to help control the mood swings of bipolar I disorder in adults, providing full-spectrum relief for all bipolar I symptoms: bipolar I depression and acute manic or mixed episodes.
Studies have shown VRAYLAR can:
- Improve overall depressive and manic symptoms*†
- Treat mixed episodes (symptoms of depression and mania at the same time)*
- Reduce the overall severity of the condition. This was observed in three 3-week mania studies.‡
*VRAYLAR was not studied to measure symptoms individually.
†At 3 weeks in 3 manic/mixed episode studies; at 6 weeks in 3 bipolar I depression studies.
‡Based on a specific research tool used by healthcare providers.

Who is VRAYLAR for?
VRAYLAR is approved in adults to treat bipolar I depression and for the short-term treatment of manic or mixed episodes that happen with bipolar I disorder. While anyone can develop bipolar I disorder, it often starts in the late teen or early adult years and lasts a lifetime.
Since VRAYLAR was introduced in 2015, it has already been used by more than 600,000 people.*
Find an effective treatment plan that works for you. Read on >
*Inclusive of all VRAYLAR indications.

See Christine’s story with bipolar l disorder
How do I take VRAYLAR?
Treatments like VRAYLAR start working gradually. Every patient is different. So, it’s important to talk to your healthcare provider about how VRAYLAR is working for you.
Things to keep in mind when taking VRAYLAR
Take Once a Day
It’s important that you take your prescribed dose of VRAYLAR as directed, even if you start to feel better.
Take by Mouth
Do not stop taking VRAYLAR or change how much you take without checking with your healthcare provider first.
With or Without Food
Take VRAYLAR once a day, with or without food.
What side effects are possible when taking VRAYLAR?
In clinical trials, the most common side effects were:
- Difficulty moving or slow movements
- Tremors
- Uncontrolled body movements
- Restlessness and feeling like you need to move around
- Sleepiness
- Nausea
- Vomiting
- Indigestion
Patients taking VRAYLAR experienced changes in blood sugar and cholesterol similar to those who took a placebo. In 6-week and 8-week bipolar I depression studies, patients who took VRAYLAR experienced an average weight gain of 1.2 pounds, compared to those on placebo who lost 0.2 pounds. In 3-week bipolar I mania studies, patients who took VRAYLAR experienced an average weight gain of 1.1 pounds, compared to those on placebo who gained 0.4 pounds.
Tell your healthcare provider if you have any side effect that bothers you or that does not go away.
These are not all possible side effects of VRAYLAR.
Will VRAYLAR cause weight gain?

Weight change reported in clinical trials was ≤1.5lb.
Weight gain may occur. You and your doctor should monitor your weight regularly.
Average weight change in 6- and 8-week bipolar depression studies:



Average weight change in 3-week bipolar mania studies:


Additional Resources:
Tips for Managing Bipolar I
Discover tips that may help
manage your bipolar I disorder
Discover tips that may
help manage your
bipolar I disorder
Bipolar I Support
Sign up for wellness support
from My Mood Matters
Sign up for wellness support
from My Mood Matters
Bipolar I Questionnaire
Take this quiz that could
help your doctor determine
whether you may have
bipolar I disorder